Skip to main content
. Author manuscript; available in PMC: 2007 Sep 20.
Published in final edited form as: Exp Hematol. 2005 Dec;33(12):1427–1435. doi: 10.1016/j.exphem.2005.06.032

Figure 1.

Figure 1

Syngeneic stem cell competition models. Theoretical and experimental syngeneic nonmyeloablative transplant models were developed based on the theory that stem cell competition between host and donor determines final chimerism. Theoretical engraftment with replacement or augmentation models compared to observed engraftment. A total of 72 unperturbed 6- to 8-week-old female BALB/c mice were injected with 40 × 106 male whole marrow cells, as controls for other experiments. Mean engraftment was found to be 7.7%. Fluorescent in situ hybridization was used to obtain engraftment results and engraftment results were confirmed in many cases by Southern blot hybridization.