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. Author manuscript; available in PMC: 2008 Jul 15.
Published in final edited form as: Arch Biochem Biophys. 2007 Feb 22;463(2):168–174. doi: 10.1016/j.abb.2007.01.033

Figure 4.

Figure 4

Overview of the relationship between copper, XIAP and the apoptotic threshold. Intracellular copper accumulation induces a conformational change of XIAP, which promotes its degradation and decreases its ability to inhibit caspase-3. The net result of these changes is a lowering of the apoptotic threshold and increased cell death in response to apoptotic stimuli. COMMD1 is involved in the efflux of copper from the cell and XIAP regulates it by promoting its ubiquitination and proteosomal degradation.