Dan and Danr interact physically in vitro with themselves and with Ey and Dac. Aliquots of in vitro-translated [35S]methionine-labeled Dan, Danr, Ey, Eya, So or Dac were incubated with glutathione-agarose beads containing bound GST, GST fused to an unrelated protein (GST-Fmi), GST-Dan and GST-Danr. Bound proteins were fractionated by SDS–PAGE and visualized by autoradiography. 10% of the input is loaded for each in vitro-translated protein for reference. Both GST-Danr and GST-Dan interact specifically with in vitro-translated Dan, Ey and Dac. For extension of this analysis by yeast two-hybrid data see Table 2.