Table 1.
Lack of mutagenicity by arsenite (24 hour exposure) in Chinese hamster V79 cells at the HPRT locus and in the derivative G12 cells at the transgenic gpt locus at high cell survival levels (Data from Li, 1988)
Cells (locus) | Arsenite (μM) | % Survival | Mutants | Mutant fraction (per 106) |
---|---|---|---|---|
V79 (HPRT) | 0 | (100) | 1 | 1.15 |
5 | 97.7 | 0 | <1.26 | |
10 | 62.4 | 0 | <2.15 | |
15 | 30.5 | 1 | 3.39 | |
20 | 10.9 | 3 | 10.20 | |
G12 (gpt) | 0 | (100) | 22 | 40.2 |
5 | 88.5 | 34 | 52.8 | |
10 | 69.2 | 33 | 60.2 | |
15 | 38.1 | 30 | 66.4 | |
20 | 21.4 | 40 | 107.9 |