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. 1984 May;82(1):9–14. doi: 10.1111/j.1476-5381.1984.tb16436.x

The actions of cirazoline on the rat vas deferens.

J R Docherty, J C McGrath
PMCID: PMC1987249  PMID: 6145469

Abstract

The pre- and postsynaptic effects of the alpha 1-agonist cirazoline were assessed in epididymal and prostatic portions of the rat isolated vas deferens. Cirazoline produced a postsynaptic alpha 1-adrenoceptor mediated potentiation of the isometric contraction to single pulse field stimulation in both prostatic and epididymal portions. In epididymal portions, nifedipine (10 microM) greatly attenuated the postsynaptic alpha 1-receptor mediated potentiation of nerve mediated contractions, uncovering a presynaptic inhibitory action of cirazoline . No evidence was found for alpha 2-antagonism by cirazoline . It is concluded that the previously reported antagonism of the presynaptic inhibitory effects of clonidine was due to postsynaptic potentiation of nerve-mediated responses by cirazoline .

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Selected References

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