Table 2.
Species | Implantation Site | Sensitivity (nA/mmol per litre) | Background Current (nA) | Response Time | |||
---|---|---|---|---|---|---|---|
In Vitro | In Vivo | In Vitro | In Vivo | In Vitro | In Vivo | ||
Rats after 3 days[66] | Interscapular subcutaneous tissue | 1.7 ± 0.2 | 0.5 ± 0.1 | 1.9 ± 0.4 | 5.8 ± 1.4 | 190 ± 0.4 s (T90%)* | < 300 s |
Dogs after 36 hours [41] | Neck subcutaneous tissue | 1.7 ± 0.7 | 1.6 ± 0.8 | 1.4 ± 0.4 | 1.3 ± 0.5 | < 300 s (T95%)† | Not provided |
Humans after 7 hours [43] | Abdominal subcutaneous tissue | 0.7 ± 0.3 | 0.2 ± 0.1 | 0.3 ± 0.1 | 1.1 ± 0.1 | 24 s (T90%)* | Not provided |
Dogs after 10 days [74] | Interscapular subcutaneous tissue | ~ 6 | ~ 3 | Not provided | Not provided | Not provided | Not Provided |
Humans after 2 hours [44] | Abdominal subcutaneous tissue | 0.4 ±0.1 | 0.1 ± 0.02 | 0.4 ± 0.2 | 0.9 ± 0.3 | 290 ± 110 s | 580 ± 290 s |
T90% refers to the time required to reach 90% of the in vitro steady-state response after a step change in bulk glucose concentration
T95% refers to the time required to reach 95% of the in vitro steady-state response after a step change in bulk glucose concentration