Figure 3.

The focal adhesion pathway as impacted in lung adenocarcinoma vs. normal. In this condition, both ITG and RTK receptors are perturbed, as well as the VEGF ligand. Because these three genes appear at the very beginning and affect both entry points controlling this pathway, their perturbations are widely propagated throughout the pathway and this pathway appears as highly impacted. All classical approaches completely ignore the positions of the genes on the given pathways and fail to identify this pathway as significant.