Figure 5.

A comparison between the results of the classical probabilistic approach (A) and the results of the impact analysis (B) for a set of genes found to be differentially expressed in a hepatic cell line treated with palmitate. Green pathways are well supported by literature evidence, while red pathways are unlikely to be relevant. The classical statistical analysis yields three pathways significant at the 5% level: complement and coagulation cascades, focal adhesion, and MAPK. The impact analysis agrees on these three pathways but also identifies several additional pathways. Among these, tight junction is well supported by the literature.