Table 1.
IC50 | ||||
---|---|---|---|---|
Doxorubicin (μM) | Vinblastine (nM) | Hydroxyurea (μM) | ||
NCI/ADR-RES | NT siRNA | 17 ± 2 | 293 ± 15 | 125 ± 15 |
CtBP1 siRNA | 6.3 ± 0.3* | 95 ± 6** | 130 ± 9 | |
A2780DX | NT siRNA | 1.2 ± 0.1 | 55 ± 2 | |
CtBP1 siRNA | 0.3 ± 0.1** | 25 ± 5* |
IC50 is the concentration of a drug that inhibited 50% cell viability compared to vehicle-treated controls in MTT assay. Results are the mean ± standard error of three separate experiments.
p < 0.05 versus NT siRNA treatment;
p < 0.01 versus NT siRNA treatment.