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. Author manuscript; available in PMC: 2008 Apr 1.
Published in final edited form as: Heart Rhythm. 2006 Dec 28;4(4):487–496. doi: 10.1016/j.hrthm.2006.12.033

Figure 1. pHo effect on homomeric Kir2.1 and Kir2.3 channels in HEK293 cells.

Figure 1

A. Acidification to pHo = 5.0 from control (pHo = 7.4) has no significant effect on whole-cell Kir2.1 current B. Peak inward (filled squares) and peak outward (open squares) Kir2.1 whole-cell currents normalized to current values at pHo = 7.4 and plotted as a function of pHo (n = 6–10). C. Acidification to pHo = 5.0 from control (pHo = 7.4) significantly inhibits whole-cell Kir2.3 current D. Peak inward (filled circles) and peak outward (open circles) Kir2.3 whole-cell currents normalized to current values at pHo = 7.4 and plotted as a function of pHo (n = 7–11). Increases in pHo blocked whole-cell inward and outward currents. See text for details.