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. Author manuscript; available in PMC: 2008 Mar 15.

Published in final edited form as: Free Radic Biol Med. 2006 Dec 14;42(6):811–822. doi: 10.1016/j.freeradbiomed.2006.12.007

Sensitivity of NO production by NOS to O₂ concentration. The concentration of NOS1 was set at 0.9 μM and the concentration of L-arginine was set at 100 μM. (A) The time course of NO production by NOS1 at different ambient O₂ concentrations in the physiological range of 5–200 μM. (B) The sensitivity of NO steady-state production by NOS1 to ambient O₂ concentrations of up to 4000 μM. The Michaelis constant (K_m) of NOS1 for O₂ can be estimated from the sensitivity test.

Sensitivity of NO production by NOS to O₂ concentration. The concentration of NOS1 was set at 0.9 μM and the concentration of L-arginine was set at 100 μM. (A) The time course of NO production by NOS1 at different ambient O₂ concentrations in the physiological range of 5–200 μM. (B) The sensitivity of NO steady-state production by NOS1 to ambient O₂ concentrations of up to 4000 μM. The Michaelis constant (K_m) of NOS1 for O₂ can be estimated from the sensitivity test.