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Thermodynamic cycle for point mutation of a dimerizing transmembrane α-helix. Red arrows indicate the change in association state (monomer to dimer), and blue arrows indicate that one residue is being mutated (triangle to circle). The change in free energy of dimerization caused by a mutation, ΔΔGmut, may be obtained from experimental data (ΔG2 − ΔG1) or by computation (ΔG4 − ΔG3).
