Figure 7.

Correlation of calculated dimerization propensity and apparent free energy of dissociation for wild type and 33 multiple mutants of GpA. Values for calc, using Eq. 4, are shown to be strongly correlated with the apparent free energies of dissociation, ΔG_app, computed by using Eq. 5 and data from refs. 22 and 23). Excluding the outlier, the squared correlation coefficient, R², is 0.845 and the slope is 0.85 (±0.07) kcal⁻¹. Triangles indicate data points corresponding to sequences depicted in Fig. 6.