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Deletional and mutational analysis of the cis-elements required for LMP1-induced MMP9 promoter activity. Arrow indicates transcription start site and “X” the sites of mutation in the MMP9 5′ flanking sequence inserted upstream of the CAT gene. Open and solid bars represent CAT activity of pcDNA3 and cytomegalovirus-LMP1-transfected C33A cells, respectively. The mean values and error bars represent the results of two sets of three experiments.
