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. Author manuscript; available in PMC: 2007 Sep 20.
Published in final edited form as: Invest Ophthalmol Vis Sci. 2004 Jan;45(1):48–58. doi: 10.1167/iovs.03-0774

Figure 8.

Figure 8

Effects of antisense oligonucleotides microinjected into the subretinal space. (A) In situ hybridization detection of neuroD mRNA in the retinal neuroepithelium with injection of medium alone and (B) in the contralateral eye. (C) neuroD mRNA in the retinal neuroepithelium injected with antisense oligonucleotides and (D) in the contralateral eye. (E) In situ hybridization detection of visinin mRNA in the retinal neuroepithelium with injection of sense oligonucleotides and (F) in the contralateral eye. (G) Visinin mRNA in the retinal neuroepithelium with injection of antisense oligonucleotides (H) in the contralateral eye. (I) Islet-1+ (immunostaining) cells in the retinal neuroepithelium injected with antisense oligonucleotides and (J) in the contralateral eye. (*) RPE. The gap between the RPE and retinal neuroepithelium in (A), (C), and (E) indicates retinal detachment from microinjection. Magnification: ×50.