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. 2007 Sep 21;3(9):e172. doi: 10.1371/journal.pcbi.0030172

Figure 3. Results from Hitting Time Analysis for Four Enzymes.

Figure 3

(A) HIV-1 protease (1a30, [21]), (B) Ricin (1br6, [22]), (C) Human rhinovirus 3C protease (1cqq, [23]), and (D) Endo-1,4-xylanase (1bvv, [24]). The plots reveal the tendency of catalytic residues (D25 and D30 in (A), Y80, V81, G121, Y123, E177, and R180 in (B), H40, E71, G145, and C147 in (C), and Y69, E78, and E172 in (D); red dots) to exhibit fast and precise communication, in accord with the results for phospholipase A2 (Figure 2). Ligand-binding residues are shown by blue dots. The catalytic residues with the highest communication propensity are labeled.