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IGF-1 and stromally expressed c-Jun regulate cell cycle proteins in prostate epithelial cells. A: Cyclin D1, D2, and D3 protein levels increased in BPH-1 cells with exogenous IGF-1 (24-hour exposure) and with c-jun+/+ co-cultures. B: CDK4 and CDK6 protein levels in BPH-1 cells did not change significantly with either exogenous IGF-1 or with c-jun+/+ co-cultures. C: CDK inhibitor p27 protein levels are decreased with exogenous IGF-1 or with c-jun+/+ co-cultures.
