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IGF-1 and stromally expressed c-Jun up-regulate cyclin D levels and stimulate BPH-1 proliferation in a PI3K/Akt-dependent manner. Cell proliferation assay (A) and Western blot analysis (B) in the presence or absence of the PI3K/Akt inhibitor LY294002. C: Phospho-Akt and cyclin D protein levels in the presence of IGF-1 receptor inhibitor I-OMe-AG538 in monocultures and co-cultures.
