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. 2007 Oct;171(4):1281–1290. doi: 10.2353/ajpath.2007.070472

Figure 4.

Figure 4

tPA mediates cerebral ischemia-induced LRP expression in the ischemic brain. A: Quantitative RT-PCR analysis of LRP expression in brain extracts from WT (black bars) and tPA−/− mice (white bars) 0.1 to 72 hours after MCAO. Error bars described SEM. n = 7 for each observation. *P < 0.05 when compared with WT animals sacrificed 0.1 hour after MCAO. ^P < 0.05 when compared with tPA−/− mice at each time point. †P < 0.05 when compared with tPA−/− mice sacrificed 0.1 to 48 hours after MCAO. B: RT-PCR analysis of LRP expression in primary murine astrocytic and neuronal cultures exposed to OGD conditions for 4 hours and either PBS (black bars) or PBS and neuroserpin (NS, white bars). n = 3 for each observation. *P < 0.05 when compared with NS-treated cells.