Table 1.
Distribution of Cell-Type-Specific Markers, Cellular Activation Markers, and Extracellular Matrix Components in Wild-Type and Cd39-Null Mice after B16-F10 Tumor Implantation
| Normal dermis | Tumor interface | Tumor tissue | |
|---|---|---|---|
| Endothelium | |||
| PECAM-1 | |||
| Wild type | ++ | ++ | ++ |
| Cd39-null | ++ | ++ | − |
| Panendothelial marker | |||
| Wild type | ++ | ++ | ++ |
| Cd39-null | ++ | ++ | − |
| VEGFR2 receptor | |||
| Wild type | + | ++ | ++ |
| Cd39-null | + | ++ | − |
| Pericytes/myofibroblasts | |||
| α-SMA | |||
| Wild type | ++ | + | ++ |
| Cd39-null | ++ | ++ | − |
| PDGF-β receptors | |||
| Wild type | + | ++ | ++ |
| Cd39-null | + | + | − |
| NG2 | |||
| Wild type | + | ++ | ++ |
| Cd39-null | + | + | − |
| Reticular fibroblasts | |||
| Wild type | + | ++ | ++ |
| Cd39-null | + | ++ | − |
| Basal lamina | |||
| Perlecan | |||
| Wild type | ++ | + | ++* |
| Cd39-null | ++ | ++ | ++† |
| Fibrin | |||
| Wild type | − | ++ | ++ |
| Cd39-null | − | ++ | + |
| Inflammatory cells | |||
| F4/80 | |||
| Wild type | + | ++ | ++ |
| Cd39-null | + | + | + |
| Platelets | |||
| Wild type | + | ++ | ++ |
| Cd39-null | + | ++ | − |
| B cells | |||
| Wild type | + | − | − |
| Cd39-null | + | − | − |
| T cells | |||
| Wild type | + | − | − |
| Cd39-null | + | − | − |
| Granulocytes | |||
| Wild type | + | − | − |
| Cd39-null | + | − | − |
−, <5 positively stained structures/hpf; +, 5 to 15 positively stained structures/hpf; ++, >15 positively stained structures/hpf.
*
Associated with vasculature and muscle bundles.
†
Associated with tumor nests.
NA, not applicable.