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VSV(Δ51)-NIS controls the growth of myeloma tumors in bg/nu/xid mice. Mice bearing subcutaneous myeloma tumors (mean volume 100 mm3) were treated with VSV(Δ51)-NIS (2 doses of 5 × 107 TCID50/dose) and monitored for (A) tumor growth. Points, mean tumor volumes (n = 10 for test groups and n = 5 for the control groups); bars indicate SE. (B) Kaplan-Meier survival curves of mice treated with saline or VSV(Δ51)-NIS (intratumorally or intravenously). Arrows indicate virus injections.
