Table 1.

Summary of proteins coimmunoprecipitating with NPM/ALK from SUDHL-1 cells, identified by MALDI-TOF

NCBI	Protein	MW, kDa	Description
P19338	Nucleolin	77 (theoretical), 110 (apparent)	Abundant RNA/DNA-binding nucleolar protein. Plays a major role in ribosome biogenesis and implicated in other processes (eg, pre-mRNA metabolism, transcriptional repression, DNA repair, replication, and recombination).49
P23246	PSF	74 (theoretical), 100 (apparent)	RNA/DNA-binding nuclear protein involved in pre-mRNA processing, transcriptional repression, DNA repair replication, and recombination.50
P07900	HSP 90-α	90	Cytoplasmic protein belonging to the heat-shock 90 family of molecular chaperones.43
P08238	HSP 90-β	90	Cytoplasmic protein belonging to the heat-shock 90 family of molecular chaperones.44
AAA58698	NPM/ALK	80	Oncogenic fusion tyrosine kinase formed by the t(2;5) chromosomal rearrangement in ALCL.7
P38646	Stress-70 protein	75	Mitochondrial protein belonging to the heat-shock 70 family. Implicated in the control of cell proliferation and cellular aging, and may act as a molecular chaperone.48
P35637	FUS/TLS	54 (theoretical), 68-75 (apparent)	Oncogenic nuclear RNA/DNA-binding protein involved in pre-mRNA processing, transcriptional activation, and DNA recombination.51
Q01844	EWS	68 (theoretical)	RNA binding protein involved in oncogenic fusion proteins with various transcription factors in sarcoma. EWS fusion proteins are potent transcriptional activators.53
P11142	HSC70	70	Heat-shock cognate 70-kDa protein is a member of the heat-shock 70 family of molecular chaperones.46
Q9UI12	Vacuolar-ATP synthase subunit-H	56	Regulatory subunit of the universal proton pump required for the acidification of endosomes and lysosomes.47
Q15233	p54nrb	54	RNA/DNA-binding nuclear protein involved in pre-mRNA processing, transcriptional activation, and DNA repair replication.52

Proteins were identified in 6 independent experiments.