Figure 1.
Epinephrine induces increased human and murine SS RBC adhesion to murine EOMA cells in vitro. Results are presented as percent adherent RBCs at a shear stress of 2 dynes/cm2; error bars show SEM of 3 different experiments. RBCs were sham treated or stimulated with 20 nM epinephrine (epi) for 1 minute. (A) Human RBCs: Inhibition of adhesion with antibody was performed as described in “Materials and methods.” *P < .001 compared with sham-treated normal RBCs; **P < .001 compared with epi-treated SS RBCs. (B) Murine normal and SS RBC adhesion: *P < .01 compared with sham-treated normal RBCs; **P < .001 compared with sham-treated SS RBCs.