Table 1.
The Wdr1gt allele is homozygous lethal
| Age ofembryos* | Number and genotype of embryos† |
P‡ | ||
|---|---|---|---|---|
| Wdr1+/+ | Wdr1+/gt | Wdr1gt/gt | ||
| Weaning | ||||
| Expected | 16 | 32 | 16 | — |
| Observed | 24 | 40 | 0 | < .001 |
| E10.5 | ||||
| Expected | 7 | 14 | 7 | — |
| Observed | 13 | 16 | 0 | .004 |
| E6.5 | ||||
| Expected | 9 | 18 | 9 | — |
| Observed | 14 | 21 | 2 | .024 |
| E3.5 | ||||
| Expected | 13 | 26 | 13 | — |
| Observed | 15 | 27 | 8 | .33 |
— indicates not applicable.
*
Days after conception at which morning of plug equals embryonic day 0.5.
†
Number and genotype of embryos from matings of Wdr1+/gt parents.
‡
Fischer exact testing using two-sided P values.