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Effect on NAT2 thermostability by different SNPs. Lysates were incubated at 37 °C for two hours. An aliquot was removed every 15 min from the incubation and assayed for SMZ NAT2 activity. The first order inactivation half-life was determined by linear regression. Three independent transfections were conducted to calculate the mean and standard deviation. None of the heat inactivation half-lives differed significantly (p>0.05) from NAT2 4 (Ref).
