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. 1968 Sep 21;3(5620):704–707. doi: 10.1136/bmj.3.5620.704

Effects of Iron Overload on Ascorbic Acid Metabolism*

A A Wapnick, S R Lynch, P Krawitz, H C Seftel, R W Charlton, T H Bothwell
PMCID: PMC1989646  PMID: 5673960

Abstract

Studies of the ascorbic acid status in two subjects with idiopathic haemochromatosis and in 12 with transfusional siderosis showed that all had decreased levels of white cell ascorbic acid. The urinary excretion of ascorbic acid was also diminished in those subjects in whom such measurements were made. The administration of ascorbic acid was followed by only a small rise in the urinary ascorbic acid output, while the oxalic acid levels (measured in two subjects) showed a significant rise. These findings resemble those described in siderotic Bantu, and support the thesis that increased iron stores lead to irreversible oxidation of some of the available ascorbic acid.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BOTHWELL T. H., BRADLOW B. A., JACOBS P., KEELEY K., KRAMER S., SEFTEL H., ZAIL S. IRON METABOLISM IN SCURVY WITH SPECIAL REFERENCE TO ERYTHROPOIESIS. Br J Haematol. 1964 Jan;10:50–58. doi: 10.1111/j.1365-2141.1964.tb00677.x. [DOI] [PubMed] [Google Scholar]
  2. BOTHWELL T. H., ISAACSON C. Siderosis in the bantu. A comparison of incidence in males and females. Br Med J. 1962 Feb 24;1(5277):522–524. doi: 10.1136/bmj.1.5277.522. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. BOTHWELL T. H., SEFTEL H., JACOBS P., TORRANCE J. D., BAUMSLAG N. IRON OVERLOAD IN BANTU SUBJECTS; STUDIES ON THE AVAILABILITY OF IRON IN BANTU BEER. Am J Clin Nutr. 1964 Jan;14:47–51. doi: 10.1093/ajcn/14.1.47. [DOI] [PubMed] [Google Scholar]
  4. CAFFEY J. Cooley's anemia: a review of the roentgenographic findings in the skeleton: Hickey lecture, 1957. Am J Roentgenol Radium Ther Nucl Med. 1957 Sep;78(3):381–391. [PubMed] [Google Scholar]
  5. Charlton R. W., Bothwell T. H. Hemochromatosis: dietary and genetic aspects. Prog Hematol. 1966;5:298–323. [PubMed] [Google Scholar]
  6. DELBARRE F. [Osteoporosis in hemochromatosis]. Sem Hop. 1960 Dec 20;36:3279–3294. [PubMed] [Google Scholar]
  7. DENSON K. W., BOWERS E. F. The determination of ascorbic acid in white blood cells. A comparison of W.B.C. ascorbic acid and phenolic acid excretion in elderly patients. Clin Sci. 1961 Oct;21:157–162. [PubMed] [Google Scholar]
  8. GRUSIN H., SAMUEL E. A syndrome of osteoporosis in Africans and its relationship to scurvy. Am J Clin Nutr. 1957 Nov-Dec;5(6):644–650. doi: 10.1093/ajcn/5.6.644. [DOI] [PubMed] [Google Scholar]
  9. Lundvall O., Weinfeld A. Determination of iron in urine with special reference to the desferrioxamine test. J Clin Pathol. 1967 Jul;20(4):611–615. doi: 10.1136/jcp.20.4.611. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Lynch S. R., Berelowitz I., Seftel H. C., Miller G. B., Krawitz P., Charlton R. W., Bothwell T. H. Osteoporosis in Johannesburg Bantu males. Its relationship to siderosis and ascorbic acid deficiency. Am J Clin Nutr. 1967 Aug;20(8):799–807. doi: 10.1093/ajcn/20.8.799. [DOI] [PubMed] [Google Scholar]
  11. Lynch S. R., Seftel H. C., Torrance J. D., Charlton R. W., Bothwell T. H. Accelerated oxidative catabolism of ascorbic acid in siderotic Bantu. Am J Clin Nutr. 1967 Jun;20(6):641–647. doi: 10.1093/ajcn/20.6.641. [DOI] [PubMed] [Google Scholar]
  12. SCHULZ E. J., SWANEPOEL H. Scorbutic pseudoscleroderma: an aspect of Bantu siderosis. S Afr Med J. 1962 May 12;36:367–372. [PubMed] [Google Scholar]
  13. Seftel H. C., Malkin C., Schmaman A., Abrahams C., Lynch S. R., Charlton R. W., Bothwell T. H. Osteoporosis, scurvy, and siderosis in Johannesburg bantu. Br Med J. 1966 Mar 12;1(5488):642–646. doi: 10.1136/bmj.1.5488.642. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. WALKER A. R., ARVIDSSON U. B. Iron overload in the South African Bantu. Trans R Soc Trop Med Hyg. 1953 Nov;47(6):536–548. doi: 10.1016/s0035-9203(53)80006-4. [DOI] [PubMed] [Google Scholar]

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