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. Author manuscript; available in PMC: 2007 Sep 21.
Published in final edited form as: J Biol Chem. 2005 Oct 17;280(49):40749–40756. doi: 10.1074/jbc.M505593200

FIGURE 2. Lineweaver-Burk plots for procainamide inhibition of DNMT1.

FIGURE 2

DNMT1 concentration was fixed at 100 nm for hemimethylated DNA and 200 nm for unmethylated DNA. A, procainamide inhibition of DNMT1 on hemimethylated DNA with AdoMet concentration fixed at 1 μm. Procainamide concentration was fixed at 0 μm (filled circles), 100 μm (open circles), 500 μm (filled triangles), 2 mm(open triangles), and 8 mm (filled squares). B, procainamide inhibition of DNMT1 on hemimethylated DNA with CG concentration fixed at 1 μm. Procainamide concentration was fixed at 0 μm (filled circles), 100 μm (open circles), 500 μm (filled triangles), 2 mm (open triangles), and 8 mm (filled squares). C, procainamide inhibition of DNMT1 on unmethylated DNA with AdoMet concentration fixed at 1 μm. Procainamide concentration was fixed at 0 mm (filled circles), 2 mm (open circles), 4 mm (filled triangles), and 8 mm (open triangles). D, procainamide inhibition of DNMT1 on unmethylated DNA with CG concentration fixed at 1 μm. Procainamide concentration was fixed at 0 mm (filled circles), 2 mm (open circles), 4 mm (filled triangles), and 8 mm (open triangles).