Dependence of the scaled single channel current on σc, channel radius a, and the diffusion coefficients Dc, DE; solid lines show the approximation Eq. 21 with and dashed and dotted lines show the time-dependent solution of the expressions in Eq. 12. Time is given in units of ((1 + γ)σc)−1, which is the relevant timescale for the buildup of the current. Parameter values not mentioned are in Table 1. (a) Scaled single channel current for different σc, varied from bottom to top (σc, ((1 + γ)σc)−1): (107 s−1, 0.05μs), (3 × 106 s−1, 0.17 μs), and (5 × 105 s−1, 1 μs). (b) Scaled single channel current for different channel radii a, varied from bottom to top: 100 nm, 40 nm, and 10 nm. (c) Scaled single channel current for different diffusion coefficients. The dotted lines show the current for Dc = 220 μm2 s−1 and DE from bottom to top: 10 μm2 s−1, 40 μm2 s−1, and 150 μm2 s−1, whereas the dashed lines give the current for DE = 220 μm2 s−1 and Dc from bottom to top: 10 μm2 s−1, 40 μm2 s−1, and 150 μm2 s−1.