Table 2.
Comparative genomics of the predicted proteins in the flightless region
|
D. melanogaster
|
S. cerevisiae
|
C. elegans
|
H. sapiens
|
||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Gene | Deletion | Protein, aa | Gene | Protein, aa | Location | Iden/ Sim, % | Gene | Protein, aa | Location | Iden/ Sim, % | Gene/ EST | Protein, aa | Iden/ Sim, % |
| tty | Viable | 836 | — | — | — | — | F42E11.2 | 519 | X | 16/36 | F11755 | — | — |
| fli | Lethal | 1,256 | — | — | — | — | fli | 1,257 | III | 49/70 | fli | 1,269 | 57/75 |
| dod | Viable | 166 | ESS1 | 172 | X | 46/56 | Y110A2 | 167 | I | 45/57 | dodo | 166 | 53/61 |
| pen | Viable | 737 | YDR496c | 657 | IV | 17/30 | ZK945.3 | 766 | II | 21/32 | KIAA0020 | 508 | 18/31 |
| sol | Viable | 1,597 | — | — | — | — | — | — | — | — | R40581 | — | — |
| iby | Viable | 361 | CDC 12 | 407 | VIII | 39/59 | F07A5.7 | 757 | I | 17/36 | H5, D28540 | 406 | 61/78 |
| waw | Viable | 679 | L8003.7 | 645 | XII | 44/59 | ZK1236.1 | 645 | III | 48/59 | AA780390 | — | — |
| bbx | Viable | 769 | — | — | — | — | T22H6.6 | 833 | X | 51/63 | AA040785 | — | — |
| slg | Viable | 669 | PUT1 | 476 | XII | 30/69* | F14E12.h | 516 | IV | 36/46 | F19541.1 | 826 | 32/47 |
| Hlc | Lethal | 566 | YLR276c | 594 | XII | 38/58 | C24H12.4 | 653 | II | 45/62 | R27090-2 | 483 | 41/52 |
| mst | Lethal | 574 | — | — | — | — | — | — | — | — | R17341 | — | — |
| lcs | Viable | 145 | — | — | — | — | H17B01.2 | 530 | II | 41/70 | AA305561 | — | — |
The viability of organisms homozygous deficient for each fly gene; the lengths of the different proteins; their closest relatives at the amino acid sequence level; the genomic locations in the S. cerevisiae, C. elegans, and human genomes; and the levels of amino acid sequence identity (Iden) and similarity (Sim) relative to the Drosophila protein are as shown. EST, expressed sequence tag.
*
Refers to the catalytic domain of sluggish.