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. 1998 Mar 31;95(7):3737–3742. doi: 10.1073/pnas.95.7.3737

Figure 1.

Figure 1

(a) Structure comparison of the Drosophila OTD and the human OTX proteins. The Drosophila OTD protein is 548 aa long and the human OTX1 and OTX2 proteins are 354- and 289 aa long, respectively. All three proteins have the conserved homeodomain near the amino terminus and carry a long carboxyl terminus. In addition to the homeodomain conservation, the three OTD/OTX proteins share a short Tyr-Pro—–Arg-Lys stretch immediately upstream of the homeodomain as well as a tripeptide, Phe/Tyr-Leu-Lys, at the amino terminus. Little homology exist between the nonhomeodomain regions of the Drosophila OTD and the human OTX proteins. The two human OTX proteins show strong similarity to each other in the amino terminus and weak similarity in the carboxyl-terminus. (b) Amino acid sequences of the OTD/OTX homeodomains. Dashes indicate identical residues.