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. Author manuscript; available in PMC: 2007 Sep 24.
Published in final edited form as: Bioorg Med Chem Lett. 2006 Sep 28;16(24):6209–6212. doi: 10.1016/j.bmcl.2006.09.026

Table 1.

Binding affinity of mono-substituted spermine sulfonamides.

graphic file with name nihms14124f6.jpg

Analog R Binding ED50 (μM)a
PMB --- 0.31
1 CH3(CH2)2CH2- >10,000
2 graphic file with name nihms14124t1.jpg 4877
3 graphic file with name nihms14124t2.jpg 2955
4 graphic file with name nihms14124t3.jpg 2108
5 graphic file with name nihms14124t4.jpg 1675
6 graphic file with name nihms14124t5.jpg 884
7 graphic file with name nihms14124t6.jpg 158
8 graphic file with name nihms14124t7.jpg 56
9 graphic file with name nihms14124t8.jpg 34
10 graphic file with name nihms14124t9.jpg 25
11 graphic file with name nihms14124t10.jpg 21
12 graphic file with name nihms14124t11.jpg 19
13 graphic file with name nihms14124t12.jpg 9
14 CH3(CH2)16CH2- 6
15 CH3(CH2)6CH2- 5
16 graphic file with name nihms14124t13.jpg 4
17 CH3(CH2)8CH2- 3
18 CH3(CH2)10CH2- 3
19 CH3(CH2)14CH2- 2