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. Author manuscript; available in PMC: 2007 Dec 1.

Published in final edited form as: Free Radic Biol Med. 2007 Mar 12;42(11):1632–1650. doi: 10.1016/j.freeradbiomed.2007.02.030

(A) Mice were injected with either PBS or Tempol solution prior to irradiation. After thirty days, tumor growth rates and the radiation dose that resulted in 50% local control were the same in mice treated with Tempol ( ) compared to the control group that did not receive Tempol ( ). (B) Tempol remains in the oxidized form in normal, well oxygenated tissues (bone marrow) ( ) but is reduced in hypoxic tissue, such as tumor (■), to the inactive form of the compound. (Adapted with permission from reference # 26)

Inline graphic — (A) Mice were injected with either PBS or Tempol solution prior to irradiation. After thirty days, tumor growth rates and the radiation dose that resulted in 50% local control were the same in mice treated with Tempol ( ) compared to the control group that did not receive Tempol ( ). (B) Tempol remains in the oxidized form in normal, well oxygenated tissues (bone marrow) ( ) but is reduced in hypoxic tissue, such as tumor (■), to the inactive form of the compound. (Adapted with permission from reference # 26)