Table 2.
Neural correlates of the postprandial glucagon-like peptide-1 (GLP-1) response
Brain region | GLP-1 without covariatesa |
GLP-1 with covariatesa |
||||||
---|---|---|---|---|---|---|---|---|
Coordinatesb |
P-value | Coordinatesb |
P-value | |||||
x | y | z | x | y | z | |||
L middle frontal gyrus | −36 | −1 | 47 | 0.0004 | −34 | −3 | 47 | 0.0005 |
L middle frontal gyrus | −40 | 2 | 37 | −40 | 2 | 35 | ||
L inferior frontal gyrus | −45 | 41 | −2 | 0.0004 | −45 | 39 | −4 | 0.001 |
Hypothalamus | −4 | −3 | −18 | 0.0003 | −4 | −5 | −16 | 0.007 |
Sex, age, body fat, and postprandial glucose, insulin, and free-fatty acid response.
Coordinates are from the brain atlas of Talairach and Tournoux (1988), such that x is the distance in millimetres to the right (+) or left (−) of midline, y is the distance in millimetres anterior (+) or posterior (−) to the anterior commissure, and z is the distance in millimetres superior (+) or inferior (−) to a horizontal plane through the anterior and posterior commissures.