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Representation of the dual effects of zinc in Bax-associated induction of mitochondrial apoptogenesis in malignant prostate cells. Pathway 1 represents an effect of zinc on Bax expression that increases the cellular level of Bax (TF=transcription factor). Pathway 2 represents the effect of zinc on the mitochondrial insertion and oligomerization of Bax that leads to pore formation for the release of cytochrome c
