Figure 2.
(A and B) Allele loss in AML and MDS patients with 7q- chromosome. Loss of heterozygosity was determined as described in Materials and Methods. Half-filled circle, loss of heterozygosity; filled circle, retention of both alleles; lines, noninformative. (C) Patient 7 shows an uncharacteristically small interstitial deletion. Representative autoradiograph revealing allele loss for the D7S687 and D7S525 loci. Lanes: 1, short term cultured T cells; and 2, Leukemic blasts. ∗, deleted alleles.