Figure 4.

Perfusion of coronary arteries of verapamil-treated and untreated mice. Transillumination of Microfil-perfused coronary arteries in untreated mice shows multiple constrictions (arrows) with pre- and poststenotic dilations, as well as narrow vessels with a serrated, rather than a smooth, contour (upper and middle left panels). In contrast, coronary vessels of treated Sgcb- and Sgcd-null mice (upper and middle right panels) reveal smoothly tapered vessels without signs of constriction and/or focal narrowing. Note the normal vascular perfusion of treated and untreated mdx mice (lower panel). Bar, 40 μm.