Figure 4.

IL-4 promotes the survival of activated T cells in vivo. Mice were injected in their quadricep muscles with DNA coding for SEA together with DNA coding for IL-2, IL-4, or empty vector. Forty-eight hours or 14 days later peripheral blood was harvested from the animals and percentages of CD4+ T cells bearing Vβ3 were measured by flow cytometry. Similar results were obtained from the lymph nodes of similarly treated animals. Results shown are the means and SEMs of four identically treated mice and are representative of two similar experiments.