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Weight curves (a) and serum insulin levels (b) of male MCH-transgenic heterozygotes back-bred on C57BL/6J background for seven generations. These MCH-OE mice showed a significant increase (P = 0.002, repeated measures ANOVA) in body weight on a standard (6% fat) diet. Serum insulin levels were increased threefold (P = 0.009) in the MCH-OE mice in comparison with wild-type mice.
