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. 1998 Mar 31;95(7):3821–3826. doi: 10.1073/pnas.95.7.3821

Figure 4.

Figure 4

Effective anti-CD45RB MB23G2 induces a shift towards expression of the low molecular weight CD45 isoforms in T cells. Anti-CD45 immunoblot on day 6 using cell lysates from animals that were untreated or treated wtih MB23G2 (effective) or MB4B4 (ineffective) anti-CD45RB mAb. (A) Splenic T cells (Left) and B cells (Right) from naive (untransplanted) animals. (B) Splenic T cells from islet allograft recipients. The numbered arrowheads indicate the number of alternative exons used to generate CD45 bands of each size, as defined (7, 25) and confirmed using lysates from transfectants expressing single CD45 isoforms (from K. Bottomly, Yale University).