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iNOS knockout mice are protected against Con A–induced liver injury. iNOS–/– mice and their corresponding WT were treated with Con A. Activities of plasma transaminases, i.e., ALT (a) and AST (b), were determined 1, 2, 4, 8, 12, 24, and 48 hours after Con A challenge. Data are expressed as the mean ± SEM (n = 4; AP ≤ 0.05 vs. Con A–treated WT mice).
