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. 2001 Feb 15;107(4):439–447. doi: 10.1172/JCI10613

Figure 7.

Figure 7

The iNOS-deficient mice are protected against GalN/LPS–induced liver injury. iNOS–/– mice and their corresponding WT (a and b) or BALB/c mice pretreated either with the specific iNOS inhibitor L-NIL or with saline at –36, –24, and –12 hours (c and d) were treated with GalN/LPS. Eight hours after GalN/LPS challenge, activities of plasma ALT and AST (a and c) and plasma levels of IL-6 (b and d) were determined. TNF-α plasma concentrations were detected 2 hours after GalN/LPS treatment (b and d). Data are expressed as the mean ± SEM (n = 6; AP ≤ 0.05 vs. Con A–treated WT or saline-pretreated mice).