Figure 2.

(a) In situ hybridization demonstrates strong VEGF mRNA expression in follicular keratinocytes (arrows) during mid-anagen of the induced hair cycle. Scale bar = 50 μm. (b and c) Temporal correlation of follicular VEGF mRNA expression levels (filled circles) and perifollicular angiogenesis during the induced adult hair cycle (b) and the physiological first postnatal hair cycle (c). Relative vessel area (open circles) is expressed as percentage of the maximum vessel area detected during late anagen (day 12; compare with Figure 1e).