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. 2001 Feb 15;107(4):485–493. doi: 10.1172/JCI11696

Figure 2.

Figure 2

Decreased IFN-γ–induced cell-surface expression of MHC class II IA in macrophages from aged mice. Bone marrow macrophages from young and old mice were incubated with saturating amounts of IFN-γ (300 U/ml) for the indicated times. Surface expression of MHC class II was then assessed by cytometry using specific antibodies after blocking the Fc receptors. The background level of expression in young and older macrophages was similar. The upper panel is representative of six independent experiments. In the lower panel, data are represented as the mean ± SD of six experiments. After 24, 48, and 72 hours of IFN-γ treatment, there was a significant difference (P < 0.01) between young and aged macrophages.