Figure 8.

Similar kinetics of CIITA mRNA expression in macrophages from aged and young mice after IFN-γ stimulation. Bone marrow macrophages from aged and young mice were treated with IFN-γ (300 U/ml) for the indicated times. The 18S RNA was used as an internal control of RNA load, and it was not affected by the treatment. The upper panel is representative of six independent experiments, all of which showed the same level of basal expression in young and older macrophages. In the lower panel, data are represented as the mean ± SD of six experiments. At each time point, no significant differences were found between young and aged macrophages (P > 0.05).