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Effect of peroxynitrite (50–1000 μM) on mitochondrial respiration (a) and PARS activity (b) in PARS+/+ and PARS−/− fibroblasts: effect of INH2BP (100 μM) in both cell types. ∗ and ∗∗ represent significant effects of peroxynitrite in PARS+/+ cells compared with unstimulated controls (P < 0.05, P < 0.01, respectively), # and ## represent significant effect of INH2BP in the presence of peroxynitrite (P < 0.05 and P < 0.01, respectively); n = 6–9.
