Table 2.
DNA regulatory elements lying between −1,000 bp and +165 bp of the human COX-2 gene promoter
| Element | DNA sequence | Position* |
|---|---|---|
| AP1-like | 5′-TGCCTTA-3′ | −938 to −932 bp |
| AP1-like | 5′-TGACCCG-3′ | −842 to −836 bp |
| GAS (STAT1) | 5′-TT[N5]AA-3′; 5′-TTTCCAAGAAA-3′ | −758 to −748 bp |
| SIE (STAT3) | 5′-TT[N4]AA-3′; 5′-TTCCACAA-3′ | −646 to −532 bp |
| AP1-like | 5′-TCACTAA-3′ | −566 to −560 bp |
| NF-κBd** | 5′-GGAGAGGGGATTCCCTGCGCC-3′ | −452 to −433 bp |
| AP2-like | 5′-GAACTCGGGGAGGA-3′ | −262 to −249 bp |
| NF-κBp** | 5′-AGAGTGGGGACTACCCCCTCT-3′ | −229 to −209 bp |
| AP2p** | 5′-GCCCCCACCGGG-3′ | −145 to −134 bp |
| SIE (STAT3) | 5′-TT[N4]AA-3′; 5′-TTACGCAA-3′ | −133 to −126 bp |
| SIE (STAT3) | 5′-TT[N4]AA-3′; 5′-TTTTTTAA-3′ | −124 to −117 bp |
| GAS (STAT1) | 5′-TT[N5]AA-3′; 5′-CTTATAAAAAG-3′ | −33 to −24 bp |
| TATA BOX | 5′-TTATAAAAA | −32 to −24 bp |
| TFIID (TBP) | 5′-TATA-3′ | −31 to −28 bp |
| TRXN START (↓) | 5′-AGCGACC↓AATTGTC-3′ | −7 to +7 bp |
| ATG START | 5′-ATG-3′ | +136 to +138 bp |
| Egr1(zif-268) | 5′-GTGCGCGG-3′ | +158 to +165 bp |
*Relative to the start of transcription (TRXN) at +1 bp; DNA promoter sequence data from GenBank D28235. **p = proximal; d = distal.