A |
Can some medicine make it harder to learn? |
Random assignment to FDA approved medication or placebo |
3 weekends of school-like participation over 1 month to evaluate impact of medication on learning ability. |
Allergy skin testing |
Psychological Testing |
|
B |
What are the characteristics of adolescents with mild to severe asthma? |
8 clinic visits including physical exam, spirometry, and asthma symptom/treatment questionnaires at each visit |
3 years participation to evaluate the characteristics of adolescents with mild to severe asthma. |
1 blood test |
|
C |
Can a HRCT help in studying asthma? |
spirometry test |
One day participation to examine utility of HRTC (High Resolution Computer Tomography) in studying asthma. |
HRTC x-ray |
|
D |
How to stay healthy when you have asthma? |
Random assignment to 1 of 3 levels of intervention: information only, information and 3 home visits from a health care worker, or information and 3 home visits with discussion about asthma medications |
18 month participation to evaluate different methods of helping adolescents control asthma, miss less school, and have fewer health problems |
|
E |
How much cortisol and nitric oxide do I have in my body? |
24 hr urine collection, |
36 hour hospital observation to evaluate levels of cortisol and nitric oxide. |
1 spirometry test |
3 peak flow measures |
nitric oxide levels measured every 4 hours. |
|
|
Above minimal risk studies |
|
F |
Which of these medicines works better? |
Medication change every 4 weeks |
15 week clinical trial comparing two FDA approved medication using a double blind, double dummy placebo crossover design |
3 overnight hospital stays |
8 spirometry tests |
8 Nitric Oxide measures |
6 -24hr urine collections |
|
G |
How often should asthma medicine be taken? |
Random assignment to treatment |
26 week trial to examine fixed versus as needed dosing schedule for established asthma medication. |
Medical history |
12 physical exams |
12 spirometry tests |
7 methacholine challenge tests |
1 allergy skin test |
1 electrocardiogram |
1 quality of life questionnaire |
7 urine pregnancy tests |
|
H |
How effective are these treatments for asthma over time? |
Random assignment to treatment |
5 year clinical trial comparing 2 investigational medications versus placebo |
6 comprehensive physical exams |
2 allergy skin tests |
6 Tanner Staging exams |
6 spirometry tests |
2 blood draws |
5 psychological tests |
6 methacholine challenge tests |
2 neuropsychological tests |
6 bone density measurements |
|
I |
Does this test help us to understand asthma? |
5 clinic visits including spirometry |
4 months participation to evaluate utility of sputum induction findings for asthma treatment. |
1 allergy skin test |
2 methacholine challenge tests |
2 sputum inductions |