Table 1.
Cynomolgus macaques; prevalence and cross-sectional area of periarticular osteophytes by treatment group.
OVX |
SPE |
ERT |
TOTAL |
||||
---|---|---|---|---|---|---|---|
prevalence (%)† | area (mm2)‡ | prevalence (%)† | area (mm2)‡ | prevalence (%)† | area (mm2)‡ | prevalence (%) | |
Abaxial Lateral | 46/54 (85.2%) | 0.67 ± 0.39 | 51/57 (89.5%) | 0.78 ± 0.48 | 36/54 (66.7%)a | 0.87 ± 0.68 | 133/165 (80.6%) |
Abaxial Medial | 39/54 (72.2%) | 0.38 ± 0.33 | 40/57 (70.2%) | 0.49 ± 0.41 | 29/54 (53.7%) | 0.41 ± 0.35 | 108/165 (65.5%) |
Axial Lateral Method A | 19/52 (36.5%) | 0.64 ± 0.41 | 26/53 (49.1%) | 0.59 ± 0.32 | 22/53 (41.5%) | 0.54 ± 0.21 | 67/158 (42.4%) |
Axial Medial Method A | 7/52 (13.5%) | 1.00 ± 0.67 | 7/53 (13.2%) | 1.02 ± 0.32 | 5/53 (9.4%) | 1.34 ± 0.49 | 19/158 (12.0%) |
Axial Lateral Method B | 19/52 (36.5%) | 0.64 ± 0.41 | 26/53 (49.1%) | 0.59 ± 0.32 | 22/53 (41.5%) | 0.54 ± 0.21 | 67/158 (42.4%) |
Axial Medial Method B | 39/52 (75.0%) | 1.08 ± 0.47 | 37/53 (69.8%) | 1.16 ± 0.38 | 43/53 (81.1%) | 1.20 ± 0.54 | 119/158 (75.3%) |
Prevalence data expressed as the number of subjects with osteophytes present/number of subjects in each treatment group (%).
Area data expressed as mean values ± standard deviation.
denotes a significant difference between SPE and ERT treatment groups (p<0.01).
None of the area comparisons were statistically significant across treament groups (Kruskal-Wallis test).
OVX = ovariectomized control group; SPE = soy phytoestrogen group; ERT = estrogen replacement group.