Table 1.
Patient Characteristics.
| I/D Genotype | |||||
| Total | II | ID | DD | P | |
| Controls | |||||
| Patients [n (%)] | 189 | 41 (22) | 95 (49) | 53 (28) | |
| Age in years [mean ± SD] | 67.7 ± 6.1 | 69.2 ± 6.2 | 67.9 ± 6.4 | 65.8 ± 5.0 | ns |
| Gender [n (%)] | |||||
| Men | 75 (40) | 17 (23) | 38 (51) | 20 (27) | ns |
| Women | 114 (60) | 24 (21) | 57 (50) | 33 (29) | |
| Colon cancer patients | |||||
| Patients [n (%)] | 141 | 37 (26) | 69 (49) | 35 (25) | ns |
| Age in years [mean ± SD] | 66.7 ± 12.4 | 66.1 ± 13.0 | 67.9 ± 10.7 | 65.2 ± 14.7 | ns |
| Gender [n (%)] | |||||
| Men | 83 (59) | 26 (31) | 33 (40) | 24 (29) | .033 |
| Women | 58 (41) | 11 (19) | 36 (62) | 11 (19) | |
| Localization [n (%)] | |||||
| Colon | 47 (33) | 18 (38) | 21 (45) | 8 (17) | ns |
| Sigma | 26 (18) | 5 (19) | 13 (50) | 8 (31) | |
| Rectum | 68 (48) | 14 (21) | 35 (52) | 19 (28) | |
| T-category [n (%)] | |||||
| pT1 | 10 (7) | 2 (20) | 6 (60) | 2 (20) | ns |
| pT2 | 17 (12) | 2 (12) | 11 (65) | 4 (24) | |
| pT3 | 99 (70) | 30 (30) | 44 (44) | 25 (25) | |
| pT4 | 15 (11) | 3 (20) | 8 (53) | 4 (27) | |
| Tumor diameter (mm) [mean ± SD] | |||||
| All | 47.4 ± 23.0 | 42.4 ± 12.0 | 50.8 ± 29.1 | 46.03 ± 16.9 | ns |
| Men | 47.0 ± 19.5 | 40.2 ± 12.3 | 52.3 ± 23.9 | 47.1 ± 17.3 | .058 |
| Women | 47.9 ± 27.5 | 47.6 ± 10.2 | 49.3 ± 33.5 | 43.7 ± 16.7 | ns |
| Number of lymph nodes [mean ± SD] | |||||
| Studied | 15.9 ± 5.8 | 15.7 ± 4.6 | 16.1 ± 6.2 | 15.5 ± 6.4 | ns |
| With metastases | 2.5 ± 4.1 | 2.5 ± 3.3 | 2.0 ± 4.1 | 3.3 ± 4.9 | |
| Men | 2.5 ± 3.7 | 2.9 ± 3.7 | 1.6 ± 2.9 | 3.3 ± 4.7 | |
| Women | 2.4 ± 4.7 | 1.7 ± 2.1 | 2.3 ± 5.0 | 3.5 ± 5.7 | |
| N-category [n (%)] | |||||
| pN0 | 69 (49) | 16 (23) | 38 (55) | 15 (22) | ns |
| pN1 | 37 (26) | 10 (27) | 19 (51) | 8 (22) | |
| pN2 | 35 (25) | 11 (31) | 12 (35) | 12 (35) | |
| M-category [n (%)] | |||||
| pM0 | 113 (80) | 31 (27) | 56 (50) | 26 (23) | ns |
| pM1 | 28 (20) | 6 (21) | 13 (46) | 9 (32) | |
| UICC tumor stage [n (%)] | |||||
| IA | 20 (14) | 3 (15) | 12 (60) | 5 (25) | ns |
| IB | 36 (25) | 10 (28) | 18 (50) | 8 (22) | |
| II | 3 (2) | 0 | 3 (100) | 0 | |
| IIIA | 4 (3) | 0 | 3 (75) | 1 (35) | |
| IIIB | 24 (17) | 9 (38) | 12 (50) | 3 (13) | |
| IIIC | 26 (18) | 9 (35) | 8 (31) | 9 (35) | |
| IV | 28 (20) | 6 (21) | 13 (46) | 9 (32) | |
ns, statistically not significant.