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Effect of leptin on serum corticosterone levels induced by E. coli LPS administration. Female BALB/c mice were simultaneously administered (i.p.) either saline or leptin (1 μg/g body weight) and challenged with either saline or E. coli LPS (100 μg/mouse). Serum was obtained from five animals per group 4 h after above treatment. Serum corticosterone concentration was determined by ELISA and the data are reported as mean ± SEM. *, p ≤ 0.05 compared with LPS-treated non-leptin controls.
